Finding 8 of 11
Publishable
Genetic liability to ADHD did not predict memory or thinking scores or their decline in older adults
We scored 751 older adults of European ancestry on a polygenic score for ADHD, leaving out the APOE region, and tested it against ten measures of cognition at the start and their change over time, including whether the link differed by amyloid status. Nothing was convincing: the smallest corrected p-value was 0.79. In 391 further people genotyped on a different platform it was again null (smallest corrected p 0.96), and pooling all 1,142 people gave 0.93.
| Measure | Value | n |
|---|---|---|
| Smallest corrected p-value, sequenced sample | 0.793 | 751 |
| Smallest corrected p-value, independent array sample | 0.958 | 391 |
| Smallest corrected p-value, pooled | 0.925 | 1142 |
| Score agreement between two genotyping methods | r = 0.969 | 542 |
Caveat. ADHD is not recorded in this cohort, the score captures only a few percent of ADHD liability, European ancestry only, and the second sample is mainly early-enrolled people with limited amyloid data, so the test of an amyloid interaction is weak.
Source report: /mnt/adni/prs_adhd/report.md; /home/arodrig5/adni_pipeline/out/imputed_prs_replication.md