Finding 3 of 11
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Cognitive tests alone predicted dementia better than all biomarkers combined
A model using only memory and thinking tests and one using only biomarkers (spinal fluid, MRI, PET, plus age and APOE4) were compared on the same 297 held-out people. The test-based model ranked people better (0.848 versus 0.806), and tests added 0.057 (0.036 to 0.080) on top of the biomarkers.
| Measure | Value | n |
|---|---|---|
| Biomarkers without cognition (concordance) | 0.806 (0.767-0.843) | 297 |
| Cognitive tests, extra gain beyond biomarkers | +0.057 (+0.036 to +0.080) | 297 |
Caveat. Not for stand-alone use: the tests help define the diagnosis being predicted, and most biomarker values were estimated by imputation for people who lacked them, which handicaps the biomarker side.
Source report: /home/arodrig5/adni_pipeline/out/cognitive.md