Finding 10 of 11
Publishable
In a small genetic scan the only genome-wide hit for Alzheimer's was the APOE gene region
We compared the genomes of roughly 320 cognitively normal people and people with Alzheimer's dementia. One variant in the APOE region, the best-known Alzheimer's risk gene, reached genome-wide significance (odds ratio 5.4, p = 6.4e-9); no other region did. Comparing normal with mild impairment in about 760 people found nothing significant, as expected for a sample this small. That the known gene shows up and the statistics are well behaved (inflation factor 0.97) is a useful check on the data.
| Measure | Value | n |
|---|---|---|
| Odds ratio, APOE-region variant, normal vs dementia | 5.4 | 321 |
| p-value | < 0.001 | 321 |
| Genome-wide-significant regions, normal vs dementia | 1 (APOE) | 321 |
| Genome-wide-significant regions, normal vs mild impairment | 0 | 761 |
Caveat. Only a few hundred people, so the odds ratio is inflated by comparing two extreme groups and this scan could not find new genes.
Source report: /mnt/adni/gwas_analysis/top20_CNvAD_m1_agesex_pc10.csv; /mnt/adni/gwas_analysis/lambda_gc.csv